In recent decades, industries have grown into complex and holistic ecosystems. A company can now get so big and powerful that it becomes a market in itself. The platform economy enables businesses and individuals to merge various activities in one device or app, and total supply chains are expected to be managed ethically and sustainably. In the Netherlands, powerful ecosystems can be found. Brainport Eindhoven and Wageningen University & Research reveal how collaboration between science, business and governance results in a breeding ground for life-changing developments. However, these enormous ecosystems and industries also raise questions concerning public and private governance. Who is responsible and what happens when there are conflicts of interest?